KLK6 Polyclonal Antibody for Human(Homo sapiens) | EIAab.comKLK6 Polyclonal Antibody for Human(Homo sapiens)

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KLK6 (Gene name),

Kallikrein-6 (Protein name ), KLK6_HUMAN from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

KLK6(PRSS18;PRSS9);

Protein name:

Kallikrein-6;

Alternative:

Protease M;Neurosin;Serine protease 18;SP59;Zyme;Serine protease 9;

Organism:

Human (Homo sapiens).

General Annotation

Sub Unit:

N/A

Function:

Serine protease which exhibits a preference for Arg over Lys in the substrate P1 position and for Ser or Pro in the P2 position. Shows activity against amyloid precursor protein, myelin basic protein, gelatin, casein and extracellular matrix proteins such as fibronectin, laminin, vitronectin and collagen. Degrades alpha-synuclein and prevents its polymerization, indicating that it may be involved in the pathogenesis of Parkinson disease and other synucleinopathies. May be involved in regulation of axon outgrowth following spinal cord injury. Tumor cells treated with a neutralizing KLK6 antibody migrate less than control cells, suggesting a role in invasion and metastasis.

Subcellular Location:

Secreted Nucleus nucleolus Cytoplasm Mitochondrion Microsome In brain, detected in the nucleus of glial cells and in the nucleus and cytoplasm of neurons. Detected in the mitochondrial and microsomal fractions of HEK-293 cells and released into the cytoplasm following cell stress.

Protein Attributes:

Sequence length:

244

Sequence:

50:

100:

150:

200:

244:

LVCGDHLRGL | VSWGNIPCGS | KEKPGVYTNV | CRYTNWIQKT | IQAK

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

SMR:

Q92876

UniGene:

Hs.79361

Pfam:

PF00089

KEGG:

hsa:5653

STRING:

9606.ENSP00000309148

String:

Q92876

MIM:

602652

Uniprot:

Q92876

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ELISA Kit for Human Kallikrein-6

Cat.:

E0691r

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96T

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ELISA Kit for Human Kallikrein-6

Cat.:

E0691h

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96T

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CLIA Kit for Human Kallikrein-6

Cat.:

U0691h

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96T

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CLIA Kit for Human Kallikrein-6

Cat.:

U0691r

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Packing:

96T

Polyclonal Antibody for Human Kallikrein-6

Cat.:

P0691Rb-h

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Packing:

40ug/0.2ml

Polyclonal Antibody for Human Kallikrein-6

Cat.:

P0691Rb-r

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Packing:

40ug/0.2ml

Monoclonal Antibody for Human Kallikrein-6

Protein for Human Kallikrein-6

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

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Linearity

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References

1.

"A novel protease homolog differentially expressed in breast and ovarian cancer."
Anisowicz A. , Sotiropoulou G. , Stenman G. , Mok S.C. , Sager R.
Mol. Med.2:624-636(1996) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
2.

"Molecular cloning of a novel trypsin-like serine protease (neurosin) preferentially expressed in brain."
Yamashiro K. , Tsuruoka N. , Kodama S. , Tsujimoto M. , Yamamura Y. , Tanaka T. , Nakazato H. , Yamaguchi N.
Biochim. Biophys. Acta1350:11-14(1997) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
tissue: Colon.
3.

"Zyme, a novel and potentially amyloidogenic enzyme cDNA isolated from Alzheimer's disease brain."
Little S.P. , Dixon E.P. , Norris F. , Buckley W. , Becker G.W. , Johnson M. , Dobbins J.R. , Wyrick T. , Miller J.R. , Mackellar W. , Hepburn D. , Corvalan J. , McClure D. , Liu X. , Stephenson D. , Clemens J. , Johnstone E.M.
J. Biol. Chem.272:25135-25142(1997) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
tissue: Brain.
4.

"Molecular characterization of Zyme/protease M/neurosin(PRSS9), a hormonally regulated kallikrein-like serine protease."
Yousef G.M. , Luo L.Y. , Scherer S.W. , Sotiropoulou G. , Diamandis E.P.
Genomics62:251-259(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
5.

"Sequencing and expression analysis of the serine protease gene cluster located in chromosome 19q13 region."
Gan L. , Lee I. , Smith R. , Argonza-Barrett R. , Lei H. , McCuaig J. , Moss P. , Paeper B. , Wang K.
Gene257:119-130(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
6.

"Cloning and characterization of novel isoforms of the human kallikrein 6 gene."
Pampalakis G. , Kurlender L. , Diamandis E.P. , Sotiropoulou G.
Biochem. Biophys. Res. Commun.320:54-61(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 2 AND 3)
tissue: Testis.
7.

"Multiple mechanisms underlie the aberrant expression of the human kallikrein 6 gene in breast cancer."
Pampalakis G. , Sotiropoulou G.
Biol. Chem.387:773-782(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);TISSUE SPECIFICITY
8.

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
9.

"Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
Kalnine N. , Chen X. , Rolfs A. , Halleck A. , Hines L. , Eisenstein S. , Koundinya M. , Raphael J. , Moreira D. , Kelley T. , LaBaer J. , Lin Y. , Phelan M. , Farmer A.
Submitted (2004-10) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
10.

"The DNA sequence and biology of human chromosome 19."
Grimwood J. , Gordon L.A. , Olsen A.S. , Terry A. , Schmutz J. , Lamerdin J.E. , Hellsten U. , Goodstein D. , Couronne O. , Tran-Gyamfi M. , Aerts A. , Altherr M. , Ashworth L. , Bajorek E. , Black S. , Branscomb E. , Caenepeel S. , Carrano A.V. , more...
Nature428:529-535(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
11.

Mural R.J. , Istrail S. , Sutton G.G. , Florea L. , Halpern A.L. , Mobarry C.M. , Lippert R. , Walenz B. , Shatkay H. , Dew I. , Miller J.R. , Flanigan M.J. , Edwards N.J. , Bolanos R. , Fasulo D. , Halldorsson B.V. , Hannenhalli S. , Turner R. , more...
Submitted (2005-07) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
12.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
tissue: Colon.
13.

"Immunofluorometric assay of human kallikrein 6 (zyme/protease M/neurosin) and preliminary clinical applications."
Diamandis E.P. , Yousef G.M. , Soosaipillai A.R. , Grass L. , Porter A. , Little S. , Sotiropoulou G.
Clin. Biochem.33:369-375(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBCELLULAR LOCATION;TISSUE SPECIFICITY
14.

"Localization of a novel type trypsin-like serine protease, neurosin, in brain tissues of Alzheimer's disease and Parkinson's disease."
Ogawa K. , Yamada T. , Tsujioka Y. , Taguchi J. , Takahashi M. , Tsuboi Y. , Fujino Y. , Nakajima M. , Yamamoto T. , Akatsu H. , Mitsui S. , Yamaguchi N.
Psychiatry Clin. Neurosci.54:419-426(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBCELLULAR LOCATION;TISSUE SPECIFICITY
15.

"The spectrum of human kallikrein 6 (zyme/protease M/neurosin) expression in human tissues as assessed by immunohistochemistry."
Petraki C.D. , Karavana V.N. , Skoufogiannis P.T. , Little S.P. , Howarth D.J.C. , Yousef G.M. , Diamandis E.P.
J. Histochem. Cytochem.49:1431-1441(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: TISSUE SPECIFICITY
16.

"Characterization of the enzymatic activity of human kallikrein 6: autoactivation, substrate specificity, and regulation by inhibitors."
Magklara A. , Mellati A.A. , Wasney G.A. , Little S.P. , Sotiropoulou G. , Becker G.W. , Diamandis E.P.
Biochem. Biophys. Res. Commun.307:948-955(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;ENZYME REGULATION;BIOPHYSICOCHEMICAL PROPERTIES;AUTOCATALYTIC CLEAVAGE
17.

"Alpha-synuclein degradation by serine protease neurosin: implication for pathogenesis of synucleinopathies."
Iwata A. , Maruyama M. , Akagi T. , Hashikawa T. , Kanazawa I. , Tsuji S. , Nukina N.
Hum. Mol. Genet.12:2625-2635(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;SUBCELLULAR LOCATION;TISSUE SPECIFICITY
18.

"Human kallikrein 6 degrades extracellular matrix proteins and may enhance the metastatic potential of tumour cells."
Ghosh M.C. , Grass L. , Soosaipillai A. , Sotiropoulou G. , Diamandis E.P.
Tumor Biol.25:193-199(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
19.

"Dynamic role of kallikrein 6 in traumatic spinal cord injury."
Scarisbrick I.A. , Sabharwal P. , Cruz H. , Larsen N. , Vandell A.G. , Blaber S.I. , Ameenuddin S. , Papke L.M. , Fehlings M.G. , Reeves R.K. , Blaber M. , Windebank A.J. , Rodriguez M.
Eur. J. Neurosci.24:1457-1469(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INDUCTION
20.

"Substrate specificity of human kallikrein 6: salt and glycosaminoglycan activation effects."
Angelo P.F. , Lima A.R. , Alves F.M. , Blaber S.I. , Scarisbrick I.A. , Blaber M. , Juliano L. , Juliano M.A.
J. Biol. Chem.281:3116-3126(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;ENZYME REGULATION
21.

"The autolytic regulation of human kallikrein-related peptidase 6."
Blaber S.I. , Yoon H. , Scarisbrick I.A. , Juliano M.A. , Blaber M.
Biochemistry46:5209-5217(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: AUTOCATALYTIC CLEAVAGE
22.

"The structure of human prokallikrein 6 reveals a novel activation mechanism for the kallikrein family."
Gomis-Rueth F.X. , Bayes A. , Sotiropoulou G. , Pampalakis G. , Tsetsenis T. , Villegas V. , Aviles F.X. , Coll M.
J. Biol. Chem.277:27273-27281(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.80 ANGSTROMS) OF 21-243;AUTOCATALYTIC CLEAVAGE;ACTIVE SITES;DISULFIDE BONDS
23.

"Crystal structure and biochemical characterization of human kallikrein 6 reveals that a trypsin-like kallikrein is expressed in the central nervous system."
Bernett M.J. , Blaber S.I. , Scarisbrick I.A. , Dhanarajan P. , Thompson S.M. , Blaber M.
J. Biol. Chem.277:24562-24570(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.75 ANGSTROMS) OF 22-244;PROTEIN SEQUENCE OF 22-25;FUNCTION;BIOPHYSICOCHEMICAL PROPERTIES;AUTOCATALYTIC CLEAVAGE;DISULFIDE BONDS;MASS SPECTROMETRY

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